Melanogenesis and Melasma Treatment

Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where is synthesised and stored. Melanin a complex pigment provides colour photoprotection the skin, hair, eyes of mammals. The regulation melanogenesis includes various mechanisms factors including genetic, environmental, endocrine factors. Knowledge pigmentation process important not only understand hyperpigmentation but also design treatments therapies treat them. Whitening cosmetics with anti-melanogenesis activity very popular. In present manuscript, we review signalling pathways involved skin specifically focus on alteration leads melasma results hyperpigmentation. Finally, current topical, oral, phototherapies discussed described, special emphasis cosmetics’ action.